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CDSCO & WHO Model Essential Medicines Formulary

Medicines & Drug Database A–Z

Search over 10 educational drug references. Access indications, general usage notes, precautions, and interaction warnings.

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Antidiabetic (SGLT2 Inhibitor)Prescription

Dapagliflozin

Generic: Dapagliflozin

Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus; reduction of the risk of hospitalization for heart failure in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors; treatment of heart failure with reduced or preserved ejection fraction (HFrEF/HFpEF); treatment of chronic kidney disease (CKD) at risk of progression.

⚙️ Work Mechanism:

Dapagliflozin works through the kidneys. Instead of forcing the body to use or store excess sugar, it blocks the protein in the kidneys that absorbs sugar back into the bloodstream. The excess sugar is safely flushed out of the body through the urine, effectively lowering blood sugar, reducing blood pressure, aiding weight loss, and protecting both the heart and kidneys.

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Antidiabetic (Sulfonylurea)Prescription Only

Glimepiride

Generic: Glimepiride

Type 2 diabetes mellitus

⚙️ Work Mechanism:

Glimepiride directly stimulates the pancreas to release more of its stored insulin into the bloodstream, lowering elevated blood sugar levels.

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Antidiabetic (Sulfonylurea)Prescription Only

Glipizide

Generic: Glipizide

Type 2 diabetes

⚙️ Work Mechanism:

Glipizide prompts the beta cells in the pancreas to produce and secrete extra insulin, bringing high blood sugar levels back toward normal.

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Antidiabetic (Sulfonylurea)Prescription Only

Glyburide

Generic: Glyburide

Type 2 diabetes

⚙️ Work Mechanism:

Glyburide triggers insulin secretion from the pancreas, lowering fasting and post-meal glucose levels in type 2 diabetes.

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Antidiabetic (DPP-4 Inhibitor)Prescription

Januvia

Generic: Sitagliptin

Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

⚙️ Work Mechanism:

Januvia protects the body's natural incretin gut hormones from breakdown, allowing insulin to be released only when blood sugar rises after eating.

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Antidiabetic (SGLT2 Inhibitor)Prescription

Jardiance

Generic: Empagliflozin

Improve glycemic control in type 2 diabetes; reduce risk of cardiovascular death and hospitalization in adults with heart failure.

⚙️ Work Mechanism:

Jardiance works in the kidneys to filter out excess blood sugar directly into the urine, protecting both the heart and kidneys while lowering blood sugar levels.

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Antidiabetic (Biguanides)Prescription

Metformin

Generic: Metformin Hydrochloride

Improve glycemic control in adults and children with type 2 diabetes mellitus

⚙️ Work Mechanism:

Metformin works by stopping the liver from overproducing unnecessary glucose and training muscle cells to utilize circulating sugar more effectively, without stressing the pancreas or causing low blood sugar crashes.

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Antidiabetic (DPP-4 Inhibitor)Prescription

Teneligliptin

Generic: Teneligliptin (Teneligliptin Hydrobromide Hydrate)

Adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes mellitus, either as monotherapy or in dual/triple combination therapy with metformin, sulfonylureas, glitazones, alpha-glucosidase inhibitors, SGLT2 inhibitors, or insulin; especially preferred in diabetic patients with comorbid mild, moderate, or severe chronic kidney disease (CKD) or diabetic nephropathy.

⚙️ Work Mechanism:

Teneligliptin works as an incretin enhancer. When you eat, your digestive tract produces natural gut hormones (GLP-1) that signal your pancreas to release insulin and stop releasing extra sugar into your blood. Normally, a bodily enzyme called DPP-4 quickly destroys these helpful hormones. Teneligliptin blocks DPP-4, allowing your natural gut hormones to stay active longer, naturally stabilizing your blood sugar levels after meals and throughout the day without causing weight gain or low blood sugar.

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Antidiabetic (DPP-4 Inhibitor)Prescription

Vildagliptin

Generic: Vildagliptin

Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus, as monotherapy or in dual/triple combination with metformin, sulfonylureas, or insulin.

⚙️ Work Mechanism:

Vildagliptin protects the body's natural gut hormones (incretins) from being broken down by the DPP-4 enzyme. This prompts the pancreas to release more insulin when blood sugar levels rise after eating, and tells the liver to produce less sugar, maintaining healthy glucose balance without causing sudden low blood sugar crashes.

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Antidiabetic (Alpha-Glucosidase Inhibitor)Prescription

Voglibose

Generic: Voglibose

Improvement and management of postprandial hyperglycemia in patients with type 2 diabetes mellitus when diet and exercise alone, or diet/exercise combined with oral hypoglycemic agents (such as metformin, sulfonylureas, or DPP-4 inhibitors) or insulin, do not achieve adequate glycemic control; prevention of progression from impaired glucose tolerance (IGT) to overt type 2 diabetes.

⚙️ Work Mechanism:

Voglibose works directly inside the small intestine to slow down the digestion of starchy carbohydrates and table sugars from food. By temporarily blocking the digestive enzymes (alpha-glucosidases) that break down food into glucose, it spreads out carbohydrate absorption over a longer period. This prevents dangerous post-meal blood sugar spikes without putting extra stress on the pancreas or causing low blood sugar (hypoglycemia).

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