Jardiance
Generic Name: Empagliflozin
Uses & Medical Indications
Improve glycemic control in type 2 diabetes; reduce risk of cardiovascular death and hospitalization in adults with heart failure.
Type 2 Diabetes, Heart Failure, Chronic Kidney Disease
Work Mechanism & Pharmacology
Patient Overview of Work Mechanism
Jardiance works in the kidneys to filter out excess blood sugar directly into the urine, protecting both the heart and kidneys while lowering blood sugar levels.
Clinical Mechanism of Action (MoA)
Potent, competitive, selective sodium-glucose cotransporter 2 (SGLT2) inhibitor in the proximal renal tubules. Promotes urinary excretion of excess glucose and sodium, reducing plasma glucose levels, systemic blood pressure, glomerular hyperfiltration, and cardiac preload/afterload.
Dosage & Administration Guidelines
10 mg orally once daily in the morning; may increase to 25 mg once daily.
Safety not established in pediatric patients.
No specific adjustment, but monitor for volume depletion.
25 mg daily.
Contraindicated on dialysis; dose adjustment not needed if eGFR >= 20 mL/min for heart failure/CKD indications.
No adjustment in mild/moderate hepatic impairment.
Side Effects & Safety Warnings
Urinary tract infections, mycotic genital infections, increased urination.
Ketoacidosis, urosepsis, necrotizing fasciitis of perineum (Fournier gangrene), hypotension.
Severe hypersensitivity to empagliflozin, patients on dialysis.
Assess for ketoacidosis in symptomatic patients; temporary discontinuation before surgery.
Interactions (Drugs, Food & Alcohol)
Diuretics (increased risk of hypotension), insulin secretagogues.
Can be taken with or without food.
Heavy drinking increases ketoacidosis risk.
Pregnancy & Breastfeeding Safety
Not recommended during second and third trimesters.
Not recommended due to potential for serious adverse reactions in infant kidney development.
Patient Counseling & Practical Advice
Stay well-hydrated throughout the day and practice good personal hygiene.
Take it when remembered, but never take two doses on the same day.
Blood pressure, renal function, signs of genital/urinary infection.
Related Medicines in Antidiabetic (SGLT2 Inhibitor)
When to Seek Urgent Medical Attention
Seek immediate emergency medical care (call emergency services or proceed to the nearest emergency department) if you experience signs of a life-threatening allergic reaction (anaphylaxis: facial, lip, tongue, or throat swelling causing airway obstruction), severe cutaneous blistering with skin peeling, sudden intense chest pain, or symptoms of overdose.
Content for Jardiance was synthesized from standardized public health monographs, official pharmacopoeias, and health authorities:
- Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
- World Health Organization (WHO) — Model List of Essential Medicines
- Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
- National Health Service (NHS) — Medicines A to Z Clinical Guidelines
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.