Glyburide
Generic Name: Glyburide
Uses & Medical Indications
Type 2 diabetes
Hyperglycemia
Work Mechanism & Pharmacology
Patient Overview of Work Mechanism
Glyburide triggers insulin secretion from the pancreas, lowering fasting and post-meal glucose levels in type 2 diabetes.
Clinical Mechanism of Action (MoA)
Potent second-generation sulfonylurea that binds with high affinity to beta-cell SUR1 receptors, inhibiting ATP-sensitive potassium conductance and stimulating insulin exocytosis from the pancreas.
Dosage & Administration Guidelines
2.5-5 mg daily
Not recommended
Not recommended
20 mg/day
Contraindicated in severe impairment
Start at 1.25 mg
Side Effects & Safety Warnings
Hypoglycemia, weight gain
Severe hypoglycemia
Type 1 diabetes, DKA
High risk of prolonged hypoglycemia
Interactions (Drugs, Food & Alcohol)
Beta-blockers, fluconazole
Take with first main meal
Risk of hypoglycemia
Pregnancy & Breastfeeding Safety
Use with caution
Avoid
Patient Counseling & Practical Advice
Risk of hypoglycemia, take with food
Skip if missed, do not double dose
Blood glucose, HbA1c
Related Medicines in Antidiabetic (Sulfonylurea)
When to Seek Urgent Medical Attention
Seek immediate emergency medical care (call emergency services or proceed to the nearest emergency department) if you experience signs of a life-threatening allergic reaction (anaphylaxis: facial, lip, tongue, or throat swelling causing airway obstruction), severe cutaneous blistering with skin peeling, sudden intense chest pain, or symptoms of overdose.
Content for Glyburide was synthesized from standardized public health monographs, official pharmacopoeias, and health authorities:
- Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
- World Health Organization (WHO) — Model List of Essential Medicines
- Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
- National Health Service (NHS) — Medicines A to Z Clinical Guidelines
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.