Tramadol
Generic Name: Tramadol
Seek Urgent Medical Attention If:
You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.
Uses & Medical Indications
Management of pain severe enough to require an opioid analgesic
Moderate to severe pain
Dosage & Administration Guidelines
50-100 mg every 4-6 hours as needed (IR)
Contraindicated in children < 12 years
Max 300 mg/day in patients > 75 years
400 mg/day (IR); 300 mg/day (ER)
Extend interval to every 12 hours if CrCl < 30 mL/min (max 200 mg/day)
50 mg every 12 hours in severe cirrhosis
Side Effects & Safety Warnings
Nausea, dizziness, constipation, somnolence, headache
Seizures, serotonin syndrome, respiratory depression, addiction
Significant respiratory depression, acute asthma, children <12, concomitant MAOI use
Seizure risk, Serotonin Syndrome risk, risk of addiction/abuse
Interactions (Drugs, Food & Alcohol)
MAOIs, SSRIs, SNRIs, triptans, strong CYP2D6 or CYP3A4 inhibitors
N/A
Avoid entirely; increases risk of fatal respiratory depression
Identified Clinical Drug Interactions for Tramadol:
High risk of Serotonin Syndrome (hyperthermia, neuromuscular hyperactivity, autonomic instability).
Pregnancy & Breastfeeding Safety
Prolonged use can cause neonatal opioid withdrawal syndrome
Not recommended; risk of infant sedation and respiratory depression
Patient Counseling & Practical Advice
May cause drowsiness. Avoid alcohol. Contains opioid - risk of addiction.
Take as needed. If on scheduled ER, take as soon as remembered or skip if close to next dose.
Pain relief, respiratory status, signs of misuse
Related Medicines in Opioid Analgesics
Content for Tramadol was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:
- Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
- World Health Organization (WHO) — Model List of Essential Medicines 23rd List
- Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
- National Health Service (NHS) — Medicines A to Z Clinical Guidelines
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.