Trusted, medically reviewed health information • Not a substitute for medical advice
Medically Verified MonographOTCClass: Alpha-Adrenergic Agonists

Oxymetazoline

Generic Name: Oxymetazoline

Common Brand Names: Afrin
Dosage Form:Nasal Spray
Route:Intranasal
Pregnancy Category:C
Last Reviewed:9/21/2026

Seek Urgent Medical Attention If:

You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.

Uses & Medical Indications

Temporary relief of nasal congestion due to common cold, hay fever, upper respiratory allergies

Medical Conditions Treated:

Nasal Congestion

Dosage & Administration Guidelines

Adult Dosage

2-3 sprays in each nostril every 10-12 hours

Pediatric Dosage

Same as adult for ages 6 and older; consult doctor for <6 yrs

Elderly / Geriatric Considerations

Use with caution due to cardiovascular effects

Maximum Dose Limit

2 doses in 24 hours

Renal Impairment:

No adjustment necessary

Hepatic Impairment:

No adjustment necessary

Side Effects & Safety Warnings

Common Side Effects

Nasal stinging/burning, dryness, sneezing

Serious Adverse Reactions

Rebound congestion (rhinitis medicamentosa) if used > 3 days, systemic hypertension

Contraindications:

Hypersensitivity, MAOI use within 14 days

Important Warnings & Precautions:

Do not use for more than 3 days. Use caution in heart disease, HTN, thyroid disease

Interactions (Drugs, Food & Alcohol)

Drug-Drug Interactions:

MAOIs (hypertensive crisis)

Food & Dietary Interactions:

N/A

Alcohol Interaction Warning:

No significant interaction

Pregnancy & Breastfeeding Safety

Pregnancy Safety

Consult physician before use

Breastfeeding / Lactation

Use caution; safety not established

Patient Counseling & Practical Advice

How to Take:

Do not use for more than 3 days to avoid rebound congestion.

What to Do if You Miss a Dose:

Use when needed. Do not exceed maximum daily dose.

Recommended Monitoring & Lab Tests:

Relief of congestion, blood pressure (in susceptible patients)

Trustworthy Sources & Medical Review

Content for Oxymetazoline was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:

  • Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
  • World Health Organization (WHO) — Model List of Essential Medicines 23rd List
  • Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
  • National Health Service (NHS) — Medicines A to Z Clinical Guidelines
Reviewer Credentials: PharmD, Clinical PharmacologistLast Reviewed Date: 9/21/2026

The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.