Trusted, medically reviewed health information • Not a substitute for medical advice
Medically Verified MonographPrescription OnlyClass: NSAID

Indomethacin

Generic Name: Indomethacin

Common Brand Names: Indocin
Dosage Form:Capsule, Suppository, Suspension
Route:Oral, Rectal
Pregnancy Category:C (D in 3rd trimester)
Last Reviewed:9/21/2026

Seek Urgent Medical Attention If:

You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.

Uses & Medical Indications

Moderate to severe pain, rheumatoid arthritis, gout

Medical Conditions Treated:

Acute gout, RA, osteoarthritis

Dosage & Administration Guidelines

Adult Dosage

25-50 mg 2-3 times daily

Pediatric Dosage

2-4 mg/kg/day in divided doses

Elderly / Geriatric Considerations

Use with extreme caution

Maximum Dose Limit

200 mg/day

Renal Impairment:

Avoid in advanced renal disease

Hepatic Impairment:

Use with caution

Side Effects & Safety Warnings

Common Side Effects

Headache, nausea, dyspepsia

Serious Adverse Reactions

GI bleeding, renal failure, MI, stroke

Contraindications:

Asthma, urticaria, or allergy to NSAIDs

Important Warnings & Precautions:

High risk of adverse CNS effects (headache)

Interactions (Drugs, Food & Alcohol)

Drug-Drug Interactions:

Warfarin, ACE inhibitors, diuretics

Food & Dietary Interactions:

Take with food

Alcohol Interaction Warning:

Avoid

Pregnancy & Breastfeeding Safety

Pregnancy Safety

Avoid in 3rd trimester

Breastfeeding / Lactation

Compatible, but alternatives preferred

Patient Counseling & Practical Advice

How to Take:

Report dark tarry stools or severe stomach pain

What to Do if You Miss a Dose:

Take as soon as remembered

Recommended Monitoring & Lab Tests:

CBC, chemistry profile, BP

Related Medicines in NSAID

Trustworthy Sources & Medical Review

Content for Indomethacin was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:

  • Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
  • World Health Organization (WHO) — Model List of Essential Medicines 23rd List
  • Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
  • National Health Service (NHS) — Medicines A to Z Clinical Guidelines
Reviewer Credentials: PharmD, Clinical PharmacologistLast Reviewed Date: 9/21/2026

The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.