Indomethacin
Generic Name: Indomethacin
Uses & Medical Indications
Moderate to severe pain, rheumatoid arthritis, gout
Acute gout, RA, osteoarthritis
Work Mechanism & Pharmacology
Patient Overview of Work Mechanism
Indomethacin calms inflammation and blocks chemical pain signals in the nervous system to deliver targeted relief from aches, fever, and stiffness.
Clinical Mechanism of Action (MoA)
Indomethacin reduces pain perception and inflammatory hyperalgesia by inhibiting cyclooxygenase-mediated prostaglandin synthesis or modulating central nociceptive transmission.
Dosage & Administration Guidelines
25-50 mg 2-3 times daily
2-4 mg/kg/day in divided doses
Use with extreme caution
200 mg/day
Avoid in advanced renal disease
Use with caution
Side Effects & Safety Warnings
Headache, nausea, dyspepsia
GI bleeding, renal failure, MI, stroke
Asthma, urticaria, or allergy to NSAIDs
High risk of adverse CNS effects (headache)
Interactions (Drugs, Food & Alcohol)
Warfarin, ACE inhibitors, diuretics
Take with food
Avoid
Pregnancy & Breastfeeding Safety
Avoid in 3rd trimester
Compatible, but alternatives preferred
Patient Counseling & Practical Advice
Report dark tarry stools or severe stomach pain
Take as soon as remembered
CBC, chemistry profile, BP
Related Medicines in NSAID
When to Seek Urgent Medical Attention
Seek immediate emergency medical care (call emergency services or proceed to the nearest emergency department) if you experience signs of a life-threatening allergic reaction (anaphylaxis: facial, lip, tongue, or throat swelling causing airway obstruction), severe cutaneous blistering with skin peeling, sudden intense chest pain, or symptoms of overdose.
Content for Indomethacin was synthesized from standardized public health monographs, official pharmacopoeias, and health authorities:
- Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
- World Health Organization (WHO) — Model List of Essential Medicines
- Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
- National Health Service (NHS) — Medicines A to Z Clinical Guidelines
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.