Hydroxyzine
Generic Name: Hydroxyzine
Uses & Medical Indications
Anxiety, pruritus, sedation before surgery
Anxiety, itching
Work Mechanism & Pharmacology
Patient Overview of Work Mechanism
Hydroxyzine works at the cellular level to correct underlying biochemical imbalances, reduce clinical symptoms, and support overall health.
Clinical Mechanism of Action (MoA)
Hydroxyzine exerts targeted therapeutic activity by interacting with specific cellular receptors, enzymatic pathways, or biological signaling cascades to relieve symptoms and restore physiological balance.
Dosage & Administration Guidelines
25-100 mg up to 4 times a day
0.6 mg/kg/dose every 6 hours
Start low (Beers criteria)
400 mg/day
Reduce dose by 50% in CrCl < 50
Reduce dose
Side Effects & Safety Warnings
Dry mouth, drowsiness
QT prolongation
Early pregnancy, prolonged QT interval
CNS depression
Interactions (Drugs, Food & Alcohol)
CNS depressants, QT prolonging drugs
N/A
Avoid
Pregnancy & Breastfeeding Safety
Contraindicated in early pregnancy
Not recommended
Patient Counseling & Practical Advice
May cause severe drowsiness
Take as soon as remembered
Relief of symptoms, mental status
When to Seek Urgent Medical Attention
Seek immediate emergency medical care (call emergency services or proceed to the nearest emergency department) if you experience signs of a life-threatening allergic reaction (anaphylaxis: facial, lip, tongue, or throat swelling causing airway obstruction), severe cutaneous blistering with skin peeling, sudden intense chest pain, or symptoms of overdose.
Content for Hydroxyzine was synthesized from standardized public health monographs, official pharmacopoeias, and health authorities:
- Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
- World Health Organization (WHO) — Model List of Essential Medicines
- Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
- National Health Service (NHS) — Medicines A to Z Clinical Guidelines
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.