Trusted, medically reviewed health information • Not a substitute for medical advice
Medically Verified MonographRxClass: Skeletal Muscle Relaxant

Cyclobenzaprine

Generic Name: Cyclobenzaprine

Common Brand Names: Flexeril, Amrix
Dosage Form:Tablet
Route:Oral
Pregnancy Category:B
Last Reviewed:9/21/2026

Seek Urgent Medical Attention If:

You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.

Uses & Medical Indications

Relieve muscle spasms

Medical Conditions Treated:

Acute musculoskeletal pain

Dosage & Administration Guidelines

Adult Dosage

5-10 mg 3 times daily

Pediatric Dosage

Approved > 15 years

Elderly / Geriatric Considerations

Start at 5 mg

Maximum Dose Limit

30 mg/day

Renal Impairment:

N/A

Hepatic Impairment:

Avoid in moderate to severe impairment

Side Effects & Safety Warnings

Common Side Effects

Drowsiness, dry mouth, dizziness

Serious Adverse Reactions

Arrhythmias, serotonin syndrome

Contraindications:

MAOI use within 14 days, hyperthyroidism

Important Warnings & Precautions:

May impair mental/physical abilities

Interactions (Drugs, Food & Alcohol)

Drug-Drug Interactions:

MAOIs, CNS depressants

Food & Dietary Interactions:

N/A

Alcohol Interaction Warning:

Avoid, increases CNS depression

Pregnancy & Breastfeeding Safety

Pregnancy Safety

Generally safe

Breastfeeding / Lactation

Use caution

Patient Counseling & Practical Advice

How to Take:

Avoid driving or operating machinery

What to Do if You Miss a Dose:

Take as soon as remembered

Recommended Monitoring & Lab Tests:

Symptom relief, mental status

Related Medicines in Skeletal Muscle Relaxant

Trustworthy Sources & Medical Review

Content for Cyclobenzaprine was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:

  • Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
  • World Health Organization (WHO) — Model List of Essential Medicines 23rd List
  • Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
  • National Health Service (NHS) — Medicines A to Z Clinical Guidelines
Reviewer Credentials: PharmD, Clinical PharmacologistLast Reviewed Date: 9/21/2026

The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.