Celecoxib
Generic Name: Celecoxib
Uses & Medical Indications
Relieve pain and inflammation
Osteoarthritis, Rheumatoid arthritis
Work Mechanism & Pharmacology
Patient Overview of Work Mechanism
Celecoxib calms inflammation and blocks chemical pain signals in the nervous system to deliver targeted relief from aches, fever, and stiffness.
Clinical Mechanism of Action (MoA)
Celecoxib reduces pain perception and inflammatory hyperalgesia by inhibiting cyclooxygenase-mediated prostaglandin synthesis or modulating central nociceptive transmission.
Dosage & Administration Guidelines
100-200 mg twice daily
For JRA: weight based
Use lowest effective dose
400 mg/day
Avoid in severe failure
Reduce dose in moderate impairment
Side Effects & Safety Warnings
Dyspepsia, headache
Cardiovascular events, GI bleeding
Sulfa allergy, CABG surgery
Cardiovascular and GI risks
Interactions (Drugs, Food & Alcohol)
Warfarin, ACE inhibitors
N/A
Increases GI bleed risk
Pregnancy & Breastfeeding Safety
Avoid late in pregnancy
Use caution
Patient Counseling & Practical Advice
Take with food
Take as soon as remembered
Pain relief, blood pressure
When to Seek Urgent Medical Attention
Seek immediate emergency medical care (call emergency services or proceed to the nearest emergency department) if you experience signs of a life-threatening allergic reaction (anaphylaxis: facial, lip, tongue, or throat swelling causing airway obstruction), severe cutaneous blistering with skin peeling, sudden intense chest pain, or symptoms of overdose.
Content for Celecoxib was synthesized from standardized public health monographs, official pharmacopoeias, and health authorities:
- Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
- World Health Organization (WHO) — Model List of Essential Medicines
- Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
- National Health Service (NHS) — Medicines A to Z Clinical Guidelines
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.